1. Bouillomides A (1) and B (2) are two depsipeptide analogues of dolastatin 13.Isolated from a Guamanian sample of Lyngbya Bouillonii, the planar structures were elucidated on the basis of HR-ESI-MS and NMR data, while the absolute configurations were determined by employing functional group conversions, modified Marfey’s analysis, and detailed analyses of ROESY correlations.